100% Allograft Demineralized Bone Fiber | Osteoinductive Potential | Excellent Handling | Rapid Rehydration | Osteoconductive Scaffold

Versatile Bone Void Solution

Demineralized bone fibers with verified osteoinductive potential.

VelvetDBF demineralized bone fiber in sterile jar with clear lid

Cervos Medical developed VelvetDBF™ to deliver a high-performance demineralized bone fiber designed for efficient handling, biologic performance, and broad clinical application.

Composed of 100% allograft cortical bone, VelvetDBF features elongated, interlocking fibers that create an osteoconductive scaffold to support cellular attachment and new bone formation. With verified osteoinductive potential and rapid rehydration using blood, BMA, PRP, or saline, VelvetDBF integrates seamlessly into surgical workflows while conforming to patient anatomy.

Schedule a Demo
Key Benefits

Engineered for the operating room.

Excellent Handling Without a Carrier

Provides a cohesive, moldable consistency that shapes easily, resists irrigation, and simplifies graft placement without added carriers.

Verified Osteoinductive Potential

Demonstrates osteoinductive potential supported by in vitro and in vivo studies, including ALP testing and evidence of new bone formation.

Rapid Rehydration & Void Filling

Rapidly hydrates with blood, BMA, PRP, or saline and expands to retain fluid, conforming to patient anatomy and filling bone voids efficiently.

Osteoconductive Fiber Architecture

A biologic scaffold to direct and support new bone formation.

SEM imaging of VelvetDBF illustrates malleable, elongated interwoven fibers, pore sizes of 100 μm+, and a rugged topography to support cellular infiltration, adhesion, and osteoconductivity.

Scanning electron micrographs of VelvetDBF fibers at 195X, 1000X, and 5000X magnification with scale bars
Clinical Applications

Indicated for homologous use in osseous defects.

VelvetDBF is intended for repair, replacement, or reconstruction of osseous defects — including filling bone voids or gaps of the skeletal system.

Trauma / Oncology

  • Non-unions
  • Fractures
  • Bone defects
  • Tumor resection

Reconstruction

  • Total joint surgery
  • Revision joint surgery
  • Fracture repair & reconstruction

Extremities

  • Total joint surgery
  • Revision joint surgery
  • Fracture repair & reconstruction

Spine

  • Cervical spine fusion
  • Lumbar spine fusion
  • Sacroiliac joint fusion
  • Scoliosis
Gloved hand holding a compressed VelvetDBF mass after rehydration
Rapidly hydrates and conforms on demand.
Preparation & Handling

Straightforward, on-demand preparation at the back table.

Watch how VelvetDBF hydrates with the surgeon's fluid of choice — blood, BMA, PRP, or saline — and shapes into a cohesive, moldable graft ready for placement.

Clinical Evidence

Osteoinductive activity demonstrated across preclinical testing.

Osteoinductive Activity of VelvetDBF™
Analysis Sample (N =) Result (Average) Control / Threshold
Alkaline Phosphatase (ALP) Activity 5 Donors 1.46 0.2 (OI assay threshold)
BMP-2 Expression (ELISA) 8 Donors Statistically higher vs. control p < 0.001
BMP-7 Expression (ELISA) 8 Donors Statistically higher vs. control p < 0.001
In Vivo Osteoinductive (OI) Score 12 Donors ~2 p < 0.001

Data derived from in vitro and in vivo testing, including ALP assays, ELISA quantification of BMP-2 and BMP-7, and an ASTM athymic nude rat model. Results demonstrate osteoinductive potential and are not intended to represent human clinical outcomes.

View the VelvetDBF™ Scientific White Paper for detailed methodology and preclinical evidence supporting osteoinductive potential.

VelvetDBF™ Products
Product # Catalog Code Product Name
01106-01P VelvetDBF 5CC 5 cc VelvetDBF (Demineralized Bone Fiber), sterile
01107-01P VelvetDBF 10CC 10 cc VelvetDBF (Demineralized Bone Fiber), sterile
77134-01M HydraCell-ORTHO-5 HydraCell Overbox: one sterile 5 cc VelvetDBF and one sterile CER-ORTHO-M device
77135-01M HydraCell-ORTHO-10 HydraCell Overbox: one sterile 10 cc VelvetDBF and one sterile CER-ORTHO-M device
77136-01M HydraCell-EXT-5 HydraCell Overbox: one sterile 5 cc VelvetDBF and one sterile CER-EXT-M device
77137-01M HydraCell-EXT-10 HydraCell Overbox: one sterile 10 cc VelvetDBF and one sterile CER-EXT-M device

Schedule a VelvetDBF™ Demo

Discover the clinical advantages of high-performance demineralized bone fiber.

Schedule a Demo